Automated Solid‐Phase Synthesis of Protected Tumor‐Associated Antigen and Blood Group Determinant Oligosaccharides

Abstract

Speedy synthesis: The development of a novel linker and monitoring each glycosylation reaction during automated solid-phase synthesis allows the rapid assembly of three Lewis-type cell-surface oligosaccharides. The synthesis of the protected tumor-marker Ley–Lex (see structure; Bn=benzyl, Piv=pivaloyl, TCA=trichloroacetyl) from monosaccharide building blocks was achieved in just 23 h, while the syntheses of Lewis X and Lewis Y required only 12 and 14 h, respectively. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z52539_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.