Randomized, Double‐Blind, Placebo‐Controlled Trial of the Effect of Vitamin D₃ on the Interferon Signature in Patients With Systemic Lupus Erythematosus

Abstract

Vitamin D3 supplementation up to 4,000 IU daily was safe and well-tolerated but failed to diminish the IFN signature in vitamin D-deficient SLE patients. Higher 25(OH)D levels sustained for a longer duration may be required to affect immunologic outcomes.