Gastrointestinal Protein Leakage in Celiac Disease

Abstract

The celiac affection as described by Gee in 1888 embraced various abdominal diseases. 1 Since then many entities have been excluded from the original concept and have attained nosological independence: fibrocystic disease of the pancreas, 2 upper intestinal infestation (lambliasis, moniliasis), 3,4 deficiency of bile salts, 5 and tuberculous enteritis. 6 Following the work of Dicke,7 van de Kamer, 8 Weijers, 9 Sheldon, 10 Frazer, 11 and others 12-14 on the harmful influence of gluten and its toxic fraction, 15-17 and following the histological examinations of the intestinal wall performed by Doniach-Shiner, 18 and Rubin, 19 it has been assumed that gluten-induced enteropathy refers to celiac disease of children and to nontropical sprue, or adult celiac disease, representing an additional entity separated out from the over-all celiac syndrome. In the common clinical description of celiac disease there is, in addition to the constant findings of pale, bulky, offensive stools with