Annals of the New York Academy of Sciences · 1982 · 343 citations · 33 references
Life SciencesBiochemistryMolecular BiologyEnzymologyLipid BiochemistryMitochondrial BiologyFatty Acid MetabolismFatty Acid SynthesisLipid BiosynthesisLipid MetabolismMitochondrial MetabolismPeroxisomal MetabolismGlycerolipid BiosynthesisGlycerolipid SynthesisLipid AcylationMitochondrial Acyl-coa MetabolismMitochondrial Fatty Acid MetabolismMitochondrial Fatty Acid SynthesisMitochondrial Lipid MetabolismPeroxisomal Lipid Metabolism
In recent years, acyl dihydroxyacetone phosphate [acyl-DHAPt) has been shown to be a precursor of glycerolipids and glycerol-ether lipids.'. ' Acyl-DHAP was discovered as a rapidly labeled lipid that was formed in crude mitochondrial fraction from 3'Pi or y-32P[ATP].3 This rapid labeling was due to the enzymatic dephosphorylation and rephosphorylation of endogenous acyl-DHAP present in the crude mitochondrial fraction (equation 1): Acyl-DHAP 2-/- Acyl-DHA (1) ADP ATP Acyl-DHAP was later shown to be biosynthesized by a direct acylation of DHAP with acyl-CoA. catalyzed by DHAP acyltransferase (EC 2.3.1.42) (equation
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