Publication | Open Access
Chemical incorporation of 1-methyladenosine into oligonucleotides
36
Citations
20
References
2002
Year
Modified NucleosideNucleic Acid ChemistryBiochemistryNatural SciencesBioconjugationOligonucleotideDna ReplicationMolecular BiologyBase MoietyChloroacetyl GroupChemical IncorporationAntisense TherapyChemical BiologyGenome Editing
The base moiety of 1-N-methyladenosine can be protected with a chloroacetyl group for incorporation of this modified nucleoside into DNA and RNA. Carefully controlled anhydrous conditions are needed for deprotection of the oligonucleotides.
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