Prospective Immunogenicity Study of Multiple Intradermal Injections of Rabies Vaccine in an Effort to Obtain an Early Immune Response without the Use of Immunoglobulin

Abstract

The present study sought to determine whether increasing and accelerating rabies vaccine administration would result in earlier protective levels of neutralizing antibody. Results indicated that the 8-site and double-dose Thai Red Cross intradermal regimens produced higher antibody titers by day 14 but not significantly higher titers by days 5 and 7. Administration of rabies immunoglobulin into and around bite wounds on the first day of rabies prophylaxis should remain the optimal postexposure treatment.