Pd–Carbene Migratory Insertion: Application to the Synthesis of Trifluoromethylated Alkenes and Dienes

Abstract

Pd-catalyzed cross-coupling of halides with CF3-substituted diazo compounds or N-tosylhydrazones has been explored for the synthesis of CF3-substituted alkenes and 1,3-butadienes. Pd-carbene migratory insertion plays the key role in these transformations.