Excessive plasma dopamine increase at rest and during exercise after long-term beta-adrenoreceptor blockade in hypertensive patients.

Abstract

The effect of four weeks and 15 months of treatment with the cardioselective beta-receptor antagonist metoprolol on blood pressures, plasma noradrenaline, adrenaline, and dopamine at rest, during submaximal steady state and near maximal exercise, as well as five minutes after exercise, was studied in seven moderately hypertensive men aged 25 to 51 years.