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Heat-Induced Up-Regulation of NAD(P)H:Quinone Oxidoreductase Potentiates Anticancer Effects of β-Lapachone

DOI

37

Citations

40

References

2005

Year

Heon Joo Park, Eun Kyung Choi, Ji-Hyung Choi, Ki-Jung Ahn, Eun Jung Kim, In-Mi Ji, Yeon Hee Kook, Seung-do Ahn, Brent Williams, Robert J. Griffin,
Clinical Cancer Research

Abstract

We observed for the first time that mild heat shock up-regulates NQO1 in tumor cells. The heat-induced up-regulation of NQO1 enhanced the anticancer effects of beta-lapachone in vitro and in vivo.

References

YearCitations

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