Light‐Regulated Release of DNA and Its Delivery to Nuclei by Means of Photolabile Gold Nanoparticles

Abstract

Light and life: A photolabile gold nanoparticle has been constructed to serve as a DNA carrier. UV irradiation causes the reversal of the nanoparticle surface charge, resulting in effective DNA release and reactivation of suppressed DNA transcription in vitro. This effect was also observed in living cells, together with efficient internalization of DNA into the nucleus. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600214_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.