Visceral Hyperalgesia Induced by Forebrain-Specific Suppression of Native Kv7/KCNQ/M-Current in Mice

Abstract

Our findings provide evidence that forebrain hyperexcitability confers visceral hyperalgesia, and suppression of central hyperexcitability by activation of KCNQ/M-channel function may provide a therapeutic potential for treatment of abdominal pain syndromes.