Concepedia

Publication | Open Access

Engagement of fatty acids with toll‐like receptor 2 drives interleukin‐1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal–induced gouty arthritis

DOIFull Paper Access

324

Citations

31

References

2010

Year

Leo A. B. Joosten, Mihai G. Netea, Eleni Mylona, Marije I. Koenders, R. K. Subbarao Malireddi, Marije Oosting, Rinke Stienstra, Frank L. van de Veerdonk, Anton F. H. Stalenhoef, Evangelos J. Giamarellos‐Bourboulis,
Arthritis & Rheumatism

Abstract

The synergistic effect between FFAs and MSU crystals leads to ASC/caspase 1-driven IL-1β release. This mechanism could explain how constitutionally derived metabolic events initiate attacks of gout via the induction of IL-1β-mediated joint inflammation.

References

YearCitations

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