Apolipoprotein E 4 and impaired episodic memory in community-dwelling elderly people: a marked sex difference. The Hordaland Health Study

Abstract

Although the harmful effect of APOE4 on episodic memory was modest in women, the risk was found to occur in about 30%. APOE4 was observed to have a dramatic effect on episodic memory in men, but only in homozygotes, who comprised about 3% of men: the whole male homozygous group showed a marked shift to lower memory scores.