Hybrid Nanomaterials that Mimic the Food Effect: Controlling Enzymatic Digestion for Enhanced Oral Drug Absorption

Abstract

Easily digested: SiO2–lipid hybrid microparticles with specific nanostructured interiors were generated from submicrometer-sized emulsion templates based on mesoporous and non-porous silica nanoparticles. These functional lipid-based microparticles can be used to mimic the pharmaceutical food effect and enhance drug absorption by controlling the enzymatic digestion of lipid colloids (see scheme; ○ oil solution, ▴ lipid–nanoparticle hybrid, □ lipid encapsulated in hybrid). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.