Concepedia

A Remarkably Efficient Coupling of Acid Chlorides with Alkynes in Water

Chen Liang, Chao‐Jun Li

Organic Letters · 2004 · 153 citations · 10 references

DOI

Concepts

Abstract

[reaction: see text] A highly effective direct coupling of acid chloride with terminal alkynes catalyzed by PdCl(2)(PPh(3))(2)/CuI together with a catalytic amount of sodium lauryl sulfate as the surfactant and K(2)CO(3) as the base provided ynones in high yields in water.

References

10

New Entry to a Three-Component Pyrimidine Synthesis by TMS−Ynones via Sonogashira Coupling

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Synthesis of Ynones by Palladium-Catalyzed Acylation of Terminal Alkynes with Acid Chlorides

Diego A. Alonso, Carmén Nájera, M. Carmen Pacheco · The Journal of Organic Chemistry · 2004 · 149 citations

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Scandium trisdodecylsulfate (STDS). A new type of lewis acid that forms stable dispersion systems with organic substrates in water and accelerates aldol reactions much faster in water than in organic solvents

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Carbon-carbon bond formation in aqueous ethanol: diastereoselective transformation of unprotected carbohydrates to higher carbon sugars using allyl bromide and tin metal

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The Barbier−Grignard-Type Carbonyl Alkylation Using Unactivated Alkyl Halides in Water

C. C. K. Keh, Chunmei Wei, Chao‐Jun Li · Journal of the American Chemical Society · 2003 · 87 citations

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