MIRD Pamphlet No. 24: Guidelines for Quantitative ¹³¹I SPECT in Dosimetry Applications

TLDR

Accurate activity estimates at each imaging time point are essential for reliable radiation dose calculations in internal radionuclide therapy, a principle outlined in MIRD 23’s overview of quantitative SPECT dosimetry. This document aims to guide the development of quantitative ¹³¹I SPECT protocols for regional and 3‑D dosimetry in radionuclide therapy. It is the first in a series of isotope‑specific guidelines following MIRD 23, focusing on the therapeutic radionuclide ¹³¹I. The recently published MIRD pamphlet no.

Abstract

The reliability of radiation dose estimates in internal radionuclide therapy is directly related to the accuracy of activity estimates obtained at each imaging time point. The recently published MIRD pamphlet no. 23 provided a general overview of quantitative SPECT imaging for dosimetry. The present document is the first in a series of isotope-specific guidelines that will follow MIRD 23 and focuses on one of the most commonly used therapeutic radionuclides, ¹³¹I. The purpose of this document is to provide guidance on the development of protocols for quantitative ¹³¹I SPECT in radionuclide therapy applications that require regional (normal organs, lesions) and 3-dimensional dosimetry.