Molecular Effects of Uptake of Gold Nanoparticles in HeLa Cells

Abstract

Mellow gold. Toxicogenomics of nanoparticles can expose subtle yet clinically relevant alterations in the intracellular environment that arise from downstream effects of nanoparticle accumulation inside cells. Genome-wide expression profiling by using DNA microarrays revealed that internalization of gold nanoparticles is not associated with gross changes in transcription in HeLa cells (see figure).