Propofol Increases Myofilament Ca2+Sensitivity and Intracellular pH via Activation of Na+–H+Exchange in Rat Ventricular Myocytes

Abstract

These results suggest that propofol increases the sensitivity of myofibrillar actomyosin ATPase to Ca2+ (ie., increases myofilament Ca2+ sensitivity), at least in part by increasing pHi via protein kinase C-dependent activation of Na+-H+ exchange.