Synthesis of Triphosphorous Bidentate Phosphine–Phosphoramidite Ligands: Application in the Highly Enantioselective Hydrogenation of <i>ortho</i>‐Substituted Aryl Enamides

Abstract

New couple: A novel combination of phosphine and phosphoramidite groups is applied to the preparation of pseudo-C2-symmetric triphosphorous bidentate phosphine–phosphoramidite ligands 1. Unprecedented enantioselectivities toward ortho-substituted aryl enamides and a 1-naphthylenamide in Rh-catalyzed hydrogenation reactions are obtained.