Nano Letters · 2004 · 711 citations · 15 references
EngineeringBioengineeringMaterials ScienceBiosensorsNanomaterialsSurface ScienceNanomaterial-based BiosensorsNanoparticle InterfacesNanoparticle SurfacesNanosensorsPlasmonic NanomaterialsPlasmonicsLocalized Surface Plasmon ResonanceLocalized Surface Plasmon Resonance BiosensorsNanoparticle AdhesionOptical PropertiesPlasmonic BiosensorsSurface Optical PropertiesSurface Plasmon Resonance BiosensorsSurface Plasmon Resonance Sensors
The localized surface plasmon resonance (LSPR) nanosensor based on the optical properties of Ag nanotriangles is shown to aid in the understanding of the interaction between amyloid β-derived diffusible ligands (ADDL) and the anti-ADDL antibody, molecules possibly involved in the development of Alzheimer's disease. By varying the concentration of anti-ADDL antibody, a surface confined binding constant of 3.0 × 10 7 M -1 for the interaction of ADDLs and anti-ADDLs was measured. Influences of Cr, the nanoparticle adhesion layer, will be shown to be the limiting factor in the sensitivity of this assay. This is the first nonmodel application of the LSPR nanosensor.
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Amanda J. Haes, Richard P. Van Duyne · Journal of the American Chemical Society · 2002 · 2K citations