Journal of Clinical Investigation · 1970 · 291 citations · 12 references
MedicineBiochemistryEndocrinologyBone MetabolismCalcium HomeostasisMineral MetabolismCalcium EndocrinologyEndocrine Regulation Of CalciumParathyroid Gland PhysiologyParathyroid Hormone PhysiologyParathyroid Hormone RegulationPhosphate HomeostasisCalcium Infusion TherapyCalcium-mediated SignalingParathyroid Cell FunctionParathyroid Gland FunctionParathyroid Hormone BiologyParathyroid Hormone Feedback RegulationParathyroid Hormone ResponseRegulation By Parathyroid Hormone
In man, oral administration of 1 g of phosphorus resulted in a 60-125% increase in serum immunoassayable parathyroid hormone (PTH) concentration. Peak PTH levels were attained in 1 hr, and PTH returned to base line levels in 2 hr. This increase in PTH appeared to be initiated by a very small decrease of total and ionized calcium and was abolished by a calcium infusion. There was no correlation between serum phosphorus and PTH. The experiments show that oral phosphorus administration initiates a calcium-mediated control system for PTH secretion and that this system operates very sensitively in man.
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IMMUNOASSAY OF BOVINE AND HUMAN PARATHYROID HORMONE
Solomon A. Berson, Rosalyn S. Yalow, G.D. Aurbach et al. · Proceedings of the National Academy of Sciences · 1963 · 441 citations · Full text