Lewis Acid Catalyzed Intramolecular [4+2] and [3+2] Cross‐Cycloaddition of Alkynylcyclopropane Ketones with Carbonyl Compounds and Imines

Abstract

One brick, two bridges: The choice of the catalyzing Lewis acid (LA, π: π-electrophilic, σ: σ-electrophilic) determines the pathway ([4+2] or [3+2]) of catalytic intramolecular cycloaddition reactions (IMCCs) of alkynylcyclopropane (ACP) ketone. This method provides a general strategy for stereoselective construction of structurally diverse bridged oxa-/aza-[n.3.1] and oxa-/aza-[n.2.1] skeletons (see scheme). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.