A DMSO‐Compatible Orienting Medium: Towards the Investigation of the Stereochemistry of Natural Products

Abstract

Organic molecules of different complexity are aligned by a DMSO-compatible gel in such a way that C–H dipolar couplings up to 29 Hz are observed. This paves the way to the simultaneous determination of conformation and configuration of organic compounds by NMR spectroscopy and thus enables the determination of the stereochemistry of natural products (e.g. hormaomycin, see picture) that cannot be crystallized. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z461267_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.