Conformational Control of Energy Transfer: A Mechanism for Biocompatible Nanocrystal‐Based Sensors

Abstract

Know when to fold 'em: Combination of a pH-triggered oligonucleotide conformational switch with fluorescent nanocrystals gives a sensitive pH nanosensor (see scheme). Analyte-dependent conformational changes control the distance between the nanocrystal energy donor (green) and a FRET acceptor (red), which results in a reporter for pH values in individual endosomes of living cells. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.