Copper‐Catalyzed Synthesis of Alkylphosphonates from <i>H</i>‐Phosphonates and <i>N</i>‐Tosylhydrazones

Abstract

Abstract A new catalytic system for the alkylation of H ‐phosphonates and diphenylphosphine oxide with N ‐tosylhydrazones has been developed. In the presence of copper(I) iodide and base, H ‐phosphonates react with N ‐tosylhydrazones to afford the corresponding coupled alkylphosphonates in good to excellent yields without any ligands. Alkylphosphonates can also be prepared in a one‐pot process directly from carbonyl compounds without the isolation of tosylhydrazone intermediates.