Inhibitory effects of <i>Lactobacillus reuteri</i> on visceral pain induced by colorectal distension in Sprague-Dawley rats

Abstract

Oral administration of either live or killed probiotic bacteria or conditioned medium inhibited the constitutive cardio-autonomic response to colorectal distension in rats through effects on enteric nerves. These data may provide a novel explanation for beneficial probiotic effects on visceral pain.