Atom‐Economic Synthesis of Optically Active Warfarin Anticoagulant over a Chiral MOF Organocatalyst

Abstract

Abstract A novel chiral metal‐organic framework (MOF) organocatalyst has been developed, based on readily available MIL‐101 and the chiral primary diamine (1 R ,2 R )‐1,2‐diphenylethylenediamine, by the post‐synthetic modification. Over the developed chiral heterogeneous catalyst the asymmetric synthesis of ( S )‐warfarin with high enantioselectivity can be fulfilled on a gram‐scale (2.8 g) with excellent yield (92%) at low cost, making the synthesis method an ideal alternative to existing methods. magnified image