Concepedia

Silver-Catalyzed Radical Tandem Cyclization for the Synthesis of 3,4-Disubstituted Dihydroquinolin-2(1<i>H</i>)-ones

Wenpeng Mai, Jitao Wang, Liangru Yang, Jinwei Yuan, Yongmei Xiao, Pu Mao, Lingbo Qu

Organic Letters · 2013 · 117 citations · 60 references

DOI

Concepts

Abstract

A silver-catalyzed tandem decarboxylative radical addition/cyclization of N-arylcinnamamides with aliphatic carboxylic acids is reported. This method affords a novel and straightforward route to various 3,4-disubstituted dihydroquinolin-2(1H)-ones in aqueous solution.

References

60

Innate C-H trifluoromethylation of heterocycles

Yining Ji, Tobias Brueckl, Ryan D. Baxter et al. · Proceedings of the National Academy of Sciences · 2011 · 755 citations

, , +12

Recent progress in the synthesis of 1,2,3,4,-tetrahydroquinolines

Alan R. Katritzky, Bogumila Rachwal · Tetrahedron · 1996 · 704 citations

, , +8

Improved Catalysts for the Palladium-Catalyzed Synthesis of Oxindoles by Amide α-Arylation. Rate Acceleration, Use of Aryl Chloride Substrates, and a New Carbene Ligand for Asymmetric Transformations

Sunwoo Lee, John F. Hartwig · The Journal of Organic Chemistry · 2001 · 526 citations

, , +16

Palladium-Catalyzed Oxidative Aryltrifluoromethylation of Activated Alkenes at Room Temperature

Xin Mu, Tao Wu, Haoyang Wang et al. · Journal of the American Chemical Society · 2011 · 486 citations

, , +8

Silver-Catalyzed Decarboxylative Fluorination of Aliphatic Carboxylic Acids in Aqueous Solution

Feng Yin, Zhentao Wang, Zhaodong Li et al. · Journal of the American Chemical Society · 2012 · 458 citations

, , +9