Early Predictors of Corticosteroid Treatment Failure in Icteric Presentations of Autoimmune Hepatitis Δ

Abstract

Approximately 20% of icteric AIH presentations fail corticosteroid therapy. This is associated with significant mortality and the need for emergency transplantation. Treatment failure is best predicted by change in MELD-Na and UKELD at day 7. Early identification of nonresponders may allow timely escalation of immunosuppression to prevent clinical deterioration.