Preeclampsia Up-Regulates Angiogenesis-Associated MicroRNA ( <i>i.e</i> ., miR-17, -20a, and -20b) That Target Ephrin-B2 and EPHB4 in Human Placenta

Abstract

miR-17, miR-20a, and miR-20b are differentially regulated in human placentas by PE. They regulate EPHB4 and ephrin-B2 expression in trophoblast and endothelial cells via the same "seed" sequence, suggesting their roles in early placental development.