Programmed Nanopatterning of Organic/Inorganic Nanoparticles Using Nanometer‐Scale Wells Embedded in a DNA Origami Scaffold

Abstract

Gold nanoparticles are selectively patterned into nanoarrays by using a punched DNA origami scaffold with nanometer-sized periodical wells. By simply adding unmodified gold nanoparticle into the solution of the punched origami scaffold, exactly one particle is captured selectively in a thiolated well. The capture is completely chemoselective such that an alternating streptavidin/gold nanoparticle heteroarray with a 26 nm period is successfully prepared.