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Are the five natural DNA/RNA base monomers a good choice from natural selection?

BiologyMolecular EcologyMedicineGeneticsEvolutionary BiologyNatural SciencesDirected EvolutionGenetic EngineeringSpecie SpecificityNatural SelectionGood ChoiceMolecular GeneticsGenetic VariationGenomicsPopulation GeneticsGenome EditingMolecular Diversity