Neurology · 1983 · 49 citations · 0 references
MedicinePharmacologyPharmacotherapyClinical PharmacologyMovement AnalysisNeuropharmacologyDrug-induced Movement DisordersMovement Disorder PharmacotherapyTremor DisordersEssential Tremor PharmacotherapyMedication-induced TremorPharmacological Treatment Of TremorValproate PharmacologyValproate-induced Tremor
Chronic valproate therapy induces symptomatic tremor in about 10% of patients. We studied the effects of propranolol, amantadine, diphenhydramine, benztropine, and cyproheptadine on these tremors in 19 patients by using serial accelerometric recordings. Propranolol was clearly the most therapeutic. Amantadine was moderately effective, but cyproheptadine, diphenhydramine, and benztropine gave little or no relief.