Concepedia

Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity

Annemie Deiteren, Joris G. De Man, Nathalie E. Ruyssers, Tom G. Moreels, Paul Pelckmans, Benedicte Y. De Winter

Gut · 2014 · 63 citations · 37 references

DOI

Abstract

H4R and H1R antagonists dose-dependently reduce and even normalise postinflammatory visceral hypersensitivity via different underlying mechanisms but with a synergistic effect. Both receptor subtypes represent promising targets for the treatment of postinflammatory visceral hypersensitivity.

References

37

Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome

Giovanni Barbara, Vincenzo Stanghellini, Roberto De Giorgio et al. · Gastroenterology · 2004 · 1.4K citations

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Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome

Giovanni Barbara, Bingxian Wang, Vincenzo Stanghellini et al. · Gastroenterology · 2007 · 757 citations · Full text

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Distinct Cytokine Patterns Identified from Multiplex Profiles of Murine DSS and TNBS-Induced Colitis

Philip Alex, Nicholas C. Zachos, Thuan T. Nguyen et al. · Inflammatory Bowel Diseases · 2008 · 739 citations · Full text

Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat

Timothy J. Ness, G. F. Gebhart · Brain Research · 1988 · 661 citations

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Role for protease activity in visceral pain in irritable bowel syndrome

Nicolas Cénac, Christopher N. Andrews, Marinella Holzhausen et al. · Journal of Clinical Investigation · 2007 · 577 citations · Full text

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