Advanced Functional Materials · 2015 · 88 citations · 33 references
Natural SciencesMaterials SciencePharmacologyChemotherapyDrug DeliveryNanomaterialsCancer NanomedicineMagnetic NanomaterialsMagnetic-responsive Drug DeliveryNanomaterials For Drug DeliveryNanomedicineNanoparticle DesignAnticancer ActivityAnticancer ChemotherapyConjugationDrug Co-deliveryElectrospun Drug Delivery SystemsElectrospun NanofibersIron Oxide NanoparticlesMagnetic Nanoparticle Drug Delivery
A method for the versatile synthesis of novel, mussel‐inspired, electrospun nanofibers with catechol moieties is reported. These mussel‐inspired nanofibers are used to bind iron oxide nanoparticles (IONPs) and the borate‐containing anticancer drug Bortezomib (BTZ) through a catechol metal binding mechanism adapted from nature. These smart nanofibers exhibit a unique conjugation of Bortezomib to their 1, 2‐benzenediol (catechol) moieties for enabling a pH‐dependent drug delivery towards the cancer cells and the IONPs via strong coordination bonds for exploiting the repeated application of hyperthermia. Thus the synergistic anticancer effect of these mussel‐inspired magnetic nanofibers were tested in vitro for the repeated application of hyperthermia along with the chemotherapy and found that the drug‐bound catecholic magnetic nanofibers exhibited excellent therapeutic efficacy for potential anticancer treatment.
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Mussel-Inspired Adhesives and Coatings
Bruce P. Lee, Phillip B. Messersmith, Jacob N. Israelachvili et al. · Annual Review of Materials Research · 2011 · 1.6K citations
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Matthew J. Harrington, Admir Mašić, Niels Holten‐Andersen et al. · Science · 2010 · 983 citations