Concepedia

The Morita–Baylis–Hillman adducts of β-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies

Mamta Dadwal, Renu Mohan, Dulal Panda, Shaikh M. Mobin, Irishi N. N. Namboothiri

Chemical Communications · 2005 · 70 citations · 19 references

DOI

Concepts

Abstract

The Morita-Baylis-Hillman (MBH) adducts of beta-aryl nitroethylenes with methyl vinyl ketone (MVK) and acrylate, formed in moderate to good yield when mediated by imidazole/LiCl in THF at room temperature, inhibit HeLa cell proliferation by binding to tubulin.

References

19

Asymmetric Michael Additions to Nitroalkenes

Otto Mathias Berner, Livio Tedeschi, Dieter Enders · European Journal of Organic Chemistry · 2002 · 834 citations

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A Tertiary Phosphine-catalyzed Reaction of Acrylic Compounds with Aldehydes

Kenichi Morita, Zennosuke Suzuki, Hiromitsu Hirose · Bulletin of the Chemical Society of Japan · 1968 · 511 citations · Full text

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Recent synthetic developments in the nitro to carbonyl conversion (Nef reaction)

Roberto Ballini, Marino Petrini · Tetrahedron · 2003 · 434 citations

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Rate Acceleration of the Baylis−Hillman Reaction in Polar Solvents (Water and Formamide). Dominant Role of Hydrogen Bonding, Not Hydrophobic Effects, Is Implicated

Varinder K. Aggarwal, David K. Dean, Andrea Mereu et al. · The Journal of Organic Chemistry · 2001 · 185 citations

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Bifunctional thiourea-catalyzed enantioselective double Michael reaction of γ,δ-unsaturated β-ketoester to nitroalkene: asymmetric synthesis of (−)-epibatidine

Yasutaka Hoashi, Takaya Yabuta, Yoshiji Takemoto · Tetrahedron Letters · 2004 · 161 citations

, , +7