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Vibration-induced hyperresponsiveness of arterial smooth muscle to noradrenaline with special reference to Raynaud's phenomenon in vibration disease
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1978
Year
Muscle FunctionVibration DiseaseArterial Smooth MuscleNeuromuscular BlockadeStimulation DeviceKinesiologyApplied PhysiologyVivo Vibratory StimulationsVibration-induced HyperresponsivenessHealth SciencesSpinal Cord InjuryDose-response RelationshipsMuscle DisordersNeurophysiologyPhysiologyElectrophysiologyAnesthesiaMedicineNeuromusculoskeletal DisorderAnesthesiology
Effects of in vitro and in vivo vibratory stimulations were studied on dose-response relationships of noradrenaline in excised femoral arteries of dogs and rats. The responsiveness of these arteries were enhanced after the application of the stimulation. The degree of the hyperresponsiveness was dependent upon frequency, amplitude, and duration of the stimulation. Based on the experimental results, a possible explanation was offered for Raynaud's phenomenon in vibration disease.