Effects of a short-term exercise training program on aerobic fitness, fatigue, health perception and activity level of subjects with multiple sclerosis

TLDR

Twenty‑six MS patients were randomized to a 4‑week, 5×30‑minute bicycle exercise program or a non‑training control, with pre‑ and post‑tests of maximal exercise capacity, gas exchange, lung function, and questionnaires on activity, fatigue, and health perception, alongside a matched healthy control group. The exercise group showed a significant shift of the aerobic threshold (VO₂ +13 %, WR +11 %), improved vitality (+46 %) and social interaction (+36 %), a 17 % rise in activity level, and a trend toward reduced fatigue, while no changes occurred in the non‑training or control groups and maximal aerobic capacity and lung function remained unchanged; compliance was 65 % and activity‑related exacerbations were only 6 %.

Abstract

Multiple sclerosis (MS) patients of an inpatient rehabilitation program have been randomly assigned to an exercise training (MS-ET) or nontraining group (MS-NI). Before and after 4 weeks of aerobic exercise training, a graded maximal exercise test with measurement of gas exchange and a lung function test was administered to all 26 patients fulfilling the inclusion criteria. Activity level, fatigue and health perception were measured by means of questionnaires. Twenty-six healthy persons served as control group and were matched in respect of age, gender and activity level. Training intervention consisted of 5×30 min sessions per week of bicycle exercise with individualised intensity. Compared with baseline, the MS training group demonstrated a significant rightward placement of the aerobic threshold (AT) (VO 2 +13%; work rate [WR])+11%), an improvement of health perception (vitality+46%; social interaction+36%), an increase of activity level (+17%) and a tendency to less fatigue. No changes were observed for the MS-NI group and the control groups. Maximal aerobic capacity and lung function were not changed by either training or nontraining in all four groups. Overall compliance to the training program was quite low (65%), whereas incidence of symptom exacerbation by physical activity has been lower than expected (6%).