Pain Medicine · 2006 · 74 citations · 8 references
MedicineNeurologyPharmacotherapyPain ManagementPain MedicinePain ScienceBotulinum Toxin TherapyBotulinum Toxin TreatmentNeuropathic PainNeuropathic Pain PharmacotherapyNociceptive PainPain ControlBotulinum NeurotoxinBotulinum ToxinsMultiple Injection StrategiesNeuropathic Pain ReliefNociceptive MechanismsPharmacological Pain Relief
Botulinum toxin type A (BTX-A) has been widely used in many clinical disorders including migraine, cervical dystonia, etc. The use of BTX-A in neuropathic pain, however, is uncommon, and the application of the anti-nociceptive effect of botulinum toxin is emerging. Here we report a case of an 80-year-old man who suffered from severe pain of post-herpetic neuralgia which was refractory to the usual therapies. However, this neuropathic pain was dramatically relieved by multiple BTX-A injection and the pain relief lasted 52 days.
8
Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
Juan Blasi, Edwin R. Chapman, Egenhard Link et al. · Nature · 1993 · 1.2K citations
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain
Minglei Cui, Sid Khanijou, John Rubino et al. · Pain · 2003 · 674 citations
Medicine, Neurobiology, Pharmacology +16