Journal of Antimicrobial Chemotherapy · 2000 · 39 citations · 9 references
Life SciencesImmunologyPharmacologyCell SignalingInflammationInnate ImmunityAnti-inflammatory PharmacologyCytokine BiologyCytokine RegulationCytokine SignalingInflammatory Cell ResponsesInflammatory SignalingCytokine Gene Expression RegulationCytokine InhibitionCytokine SynthesisImmune Cell Cytokine ProductionInflammatory Cytokine ProductionInflammatory Response To Bacterial InfectionInnate Immune CytokinesInterleukin Regulation
The effect of a new quinolone antibacterial agent, grepafloxacin, on the production of cytokines was investigated using lipopolysaccharide-stimulated human peripheral blood cells. Grepafloxacin 1-30 mg/L inhibited the production of interleukin 1alpha (IL-1alpha) and IL-1beta, and the expression of IL-1alpha, IL-1beta, tumour necrosis factor alpha (TNFalpha), IL-6 and IL-8 mRNA. These results suggest that the inhibitory effect of grepafloxacin is exerted, in part, at the gene transcription level.
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