Pharmacological Studies of Rhus Retinorrhaea

Abstract

An ethanol extract of Rhus retinorrhaea Steud. ex. A. Rich-has been studied for anti-inflammatory, antipyretic, and analgesic activities in experimental models. The extract produced significant inhibition of carrageenan-induced paw edema, an insignificant cotton pellet granuloma in rats, a significant dose-dependent reduction of yeast-induced hyperpyrexia, and inhibition of acetic acid-induced writhing in mice. Other pharmacological studies revealed central nervous system depressing and negative inotropic and chronotropic activities. The acute toxicity studies showed no mortality and adverse effects up to a 3g/kg dose in mice.