Role of Liver Function Tests in Detecting Methotrexate-Induced Liver Damage in Sarcoidosis

Abstract

Toxic reactions to methotrexate eventually occurred in more than 10% of patients with sarcoidosis treated for more than 2 years with methotrexate. Because of hepatic involvement owing to sarcoidosis, results of serial liver function tests were not useful in determining which patients would have this reaction to methotrexate.