Constraint of DNA on Functionalized Graphene Improves its Biostability and Specificity

Abstract

Single-stranded DNA constrained on a graphene surface is effectively protected from enzymatic cleavage by DNase I. Various spectroscopy studies suggest that the single-stranded DNA is promptly adsorbed onto graphene forming strong molecular interactions. Constraint of the DNA probe on the graphene surface improves the specificity of its response to complementary DNA. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.