Effects of tenidap on canine experimental osteoarthritis i. morphologic and metalloprotease analysis

Abstract

This study showed that tenidap had a more potent anti-osteoarthritic effect than diclofenac in this model. The effect of the drug in suppressing metalloprotease synthesis, a process known to play a major role in the pathophysiology of osteoarthritic lesions, may explain its mechanism of action.