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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity

Biological ActivityPhosphoinositide-dependent Kinase-1Medicinal ChemistryBiochemistryNatural SciencesMedicineReceptor Tyrosine KinaseRational Drug DesignMechanism Of ActionPharmacotherapyDrug DevelopmentChemical BiologyPharmacologyPharmaceutical ChemistryDrug Discovery