Transition metal-catalyzed direct nucleophilic addition of C–H bonds to carbon–heteroatom double bonds

Abstract

Compared with the traditional Grignard reaction, direct insertion of polar double bonds to C–H bonds<italic>via</italic>transition-metal catalysis is ideal from the viewpoint of atom-, step- and cost-economy and the avoidance of the waste emission, as well as of the complex manipulation of sensitive reagents.