Rambam Maimonides Medical Journal · 2013 · 27 citations · 120 references
MedicineCardiologySurgeryCardiothoracic SurgeryRegenerative MedicineTissue EngineeringCardiac Tissue EngineeringCardiac Valve SurgeryCongenital Heart DiseaseCongenital Heart SurgeryCongenital MalformationsCongenital Structural Heart DiseaseCardiac PatchesCongenital Cardiac AnomaliesCongenital Heart Defect RepairCongenital Valve SurgeryHeart Decellularized ScaffoldsPolymeric ScaffoldsRobot-assisted Valve RepairTranscatheter Pulmonary Valve Implantation
The surgical repair of complex congenital heart defects frequently requires additional tissue in various forms, such as patches, conduits, and valves. These devices often require replacement over a patient's lifetime because of degeneration, calcification, or lack of growth. The main new technologies in congenital cardiac surgery aim at, on the one hand, avoiding such reoperations and, on the other hand, improving long-term outcomes of devices used to repair or replace diseased structural malformations. These technologies are: 1) new patches: CorMatrix® patches made of decellularized porcine small intestinal submucosa extracellular matrix; 2) new devices: the Melody® valve (for percutaneous pulmonary valve implantation) and tissue-engineered valved conduits (either decellularized scaffolds or polymeric scaffolds); and 3) new emerging fields, such as antenatal corrective cardiac surgery or robotically assisted congenital cardiac surgical procedures. These new technologies for structural malformation surgery are still in their infancy but certainly present great promise for the future. But the translation of these emerging technologies to routine health care and public health policy will also largely depend on economic considerations, value judgments, and political factors.
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Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
April M. Kloxin, Andrea M. Kasko, Chelsea N. Salinas et al. · Science · 2009 · 1.7K citations · Full text
ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease
Carole A. Warnes, Roberta G. Williams, Thomas M. Bashore et al. · Circulation · 2008 · 861 citations · Full text
Medicine, Cardiology, Surgery +13