Journal of Neurochemistry · 1975 · 76 citations · 16 references
Synaptic TransmissionNeurotransmitterBrain CalciumPharmacotherapyNeurotransmissionExperimental PharmacologySocial SciencesNeurologyNeurochemistryAnesthetic PharmacologyMolecular NeuroscienceBehavioral PharmacologyNeuropharmacologyNervous SystemPharmacologySynaptic PlasticityNeurophysiologyNeuroanatomyCalcium PoolsPhysiologyNeuroscienceCentral Nervous SystemMedicine
Abstract— The in vivo administration of a single dose of morphine produces a decrease of tissue calcium in the rat brain. This decrease is observed to be linear, dose‐dependent, time‐dependent and to occur to an equal degree in 8 discrete brain regions. This effect of morphine is blocked by naloxone and exhibits a high degree of sterospecificity. The reserpine induced decrease of brain calcium was not antagonized by naloxone. Differentiation of this response using reserpine and naloxone indicates the possibility of calcium pools in the central nervous system. The results are discussed in terms of a specific effect of opiate drugs and the role of calcium in opiatereceptor interactions.
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Opiate Receptor: Demonstration in Nervous Tissue
Candace B. Pert, Solomon H. Snyder · Science · 1973 · 2.4K citations