Common Variants of the Novel Type 2 Diabetes Genes<i>CDKAL1</i>and<i>HHEX/IDE</i>Are Associated With Decreased Pancreatic β-Cell Function

Abstract

CDKAL1 and HHEX/IDE diabetes-associated alleles are associated with decreased pancreatic beta-cell function, including decreased beta-cell glucose sensitivity that relates insulin secretion to plasma glucose concentration. We confirmed the association between the FTO allele and increased adiposity, but none of the other novel susceptibility alleles were associated with whole-body insulin sensitivity.