Understanding the differences between contrasting HIV epidemics in east and west Africa: results from a simulation model of the Four Cities Study

Abstract

The contrasting HIV epidemics in east and west Africa could be replicated in our model by assuming that male circumcision reduced susceptibility to HIV, syphilis and chancroid. Varying rates of male circumcision may have played an important role in explaining the strikingly different HIV epidemics observed in different parts of sub-Saharan Africa.